She also appeared in Picture This with her former Degrassi: The Next Generation co-star Lauren Collins. Shenae Grimes also appeared in a music video for rock band Our Lady Peace's single, "All You Did Was Save My Life", which was filmed in April 2009.
Shenae Grimes wrote, sang, and directed the video for her song "Myself and I".
In 2010, she participated in YouTuber Freddie Wong's video "Gun Size Matters". She made a cameo in the horror film Scream 4, released in April 2011.